As reações a substâncias em contato com a pele podem ocorrer pela ação direta sobre a pele (dermatite de contato irritativa, p.ex. detergentes e água sanitária) e por mecanismos alérgicos, p.ex. bijuterias e esmaltes. Caracteriza-se pelo aparecimento da lesão na área da pele que entrou em contato com o alérgeno, e a base do tratamento consiste na descoberta da causa e seu afastamento.

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